This is an outline for a middle path between Nietschzean and Buddhist philosophy and ordinary human life. Here satisfaction and dissatisfaction are recognized as two expressions of the same human condition. Here thirst is never fully extinguished in a person's life but they enter moments of stillness where thirst is not felt and can bring this stillness into their work and personal lives. Life may not have a meaning or purpose that the identity attaches to, rather it is set up for the fulfillment of the body and a life well lived has a positive impact on others. The path to a righteous life is one that has the biggest positive influence on other beings.  

The body is designed to crave temporary pleasures such as sensuality, instant gratification, artificial dopamine release by substances, fame, money etc.. These temporary pleasures in moderation can supplement a fulfilling life. But when these temporary pleasures become the only source of satisfaction and are the only sought after ends in a person's life, then life becomes ultimately miserable as these sources of pleasure never lead to long term contentment. 

If these temporary pleasures are realized as moments of sweetness that could never create a lasting joy to the body they can be supplemented and sought after in moderation. The temporary pleasures may enhance a person's relationship with themselves and others, so long as they are not sought after without control and are not taking away from the health of their mind and body.

Kusula and akusala (skillful and unskillful actions) have the same fundamental origin and motive; to fulfill the body. Unskillful affects fulfill the body in quick bursts that release dopamine and feelings of joy that quickly diminish. Skillful affects ones that require attention, patience, perseverance, and the dopamine release is not instant but rather comes about as a product of work and learning; are joyful and satisfying but eventually diminish. Although the satisfaction lasts longer in the skillful affects as the skillful affects become a part of a person's character. When a skilled motive is practiced it is transformative and subject to change just as the person is subject to change. 

The less skillful a pleasure is the more potential it has to degenerate the character of a person, as the aim of unskillful affects is to provide an instant sense of gratification that although is impermanent the body does not recognize it so easily as impermanent. The skillful affects ones that require dedication are more recognizable to the body as impermanent and ever changing. The more a desire/motive/affect can be recognized as a transformative state where the illusion of permanence is seen through, the more skillful the affect is. The more the affect transforms the person's character for the better the more skillful it is.

References:

Morrison, R. G. (2002). Nietzsche and buddhism: A study in nihilism and ironic affinities. Oxford University Press.